Analysis of Chemical Composition and Assessment of Cytotoxic, Antimicrobial, and Antioxidant Activities of the Essential Oil of Meriandra dianthera Growing in Saudi Arabia
In: Molecules, Jg. 24 (2019-07-01), Heft 14
Online
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Zugriff:
PubMed: 31336582
The essential oil of Meriandra dianthera (Konig ex Roxb.) Benth. (Synonym: Meriandra bengalensis, Lamiaceae) collected from Saudi Arabia was studied utilizing GC and GC/MS. Forty four constituents were identified, representing 96.8% of the total oil. The M. dianthera essential oil (MDEO) was characterized by a high content of oxygenated monoterpenes (76.2%). Camphor (54.3%) was the major compound in MDEO followed by 1,8-cineole (12.2%) and camphene (10.4%). Moreover, MDEO was assessed for its cytotoxic, antimicrobial, and antioxidant activities. MDEO demonstrated an interesting cytotoxic activity against all cancer cell lines with IC50 values of 83.6 to 91.2 µg/mL, especially against MCF-7 cancer cells. Using labeling with annexin VFITC and/or propidium iodide (PI) dyes and flow cytometer analysis, the apoptosis induction was quantitatively confirmed for MCF-7 cells. The MDEO exhibited a considerable antimicrobial activity against all bacterial and fungal strains with minimum inhibitory concentration (MIC)-values of 0.07 to 1.25 mg/mL. The most sensitive microbial strain was Staphylococcus aureus (MIC: 0.07 mg/mL). Minimum bactericidal concentration (MBC) or minimum fungicidal concentration (MFC) values were determined one time higher than that of MIC’s. Additionally, the MDEO revealed a strong activity for reducing ß-carotene bleaching with a total antioxidant value of 72.6% and significant DPPH free radical scavenging activity (78.4%) at the concentration 1000 µg/mL
King Saud University, KSU Deanship of Scientific Research, King Saud University Deanship of Scientific Research, King Saud University
Funding: This research was funded by DSR (Deanship of Scientific Research) at King Saud University for funding the work through the research group project No. (RGP-073).
Acknowledgments: The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding the work through the research group project No. (RGP-073).
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Analysis of Chemical Composition and Assessment of Cytotoxic, Antimicrobial, and Antioxidant Activities of the Essential Oil of Meriandra dianthera Growing in Saudi Arabia
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Autor/in / Beteiligte Person: | Almarfadi, Omar M. ; Khaled, Jamal M. ; Kürkçüoğlu, Mine ; Noman, Omar M. ; Nasr, Fahd A. ; Mothana, Ramzi A. ; Al-Zharani, Mohammed ; Abutaha, Nael ; Al-Rehaily, Adnan J. ; Kumar, Ashok ; Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı |
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Zeitschrift: | Molecules, Jg. 24 (2019-07-01), Heft 14 |
Veröffentlichung: | MDPI, 2019 |
Medientyp: | unknown |
ISSN: | 1420-3049 (print) ; 3133-6582 (print) |
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