PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development
In: Immunity, Jg. 43 (2015-10-01), S. 674-689
Online
unknown
Zugriff:
SummaryDevelopment of dendritic cells (DCs) commences in the bone marrow, from where pre-DCs migrate to peripheral organs to differentiate into mature DCs in situ. However, the factors that regulate organ-specific differentiation to give rise to tissue-specific DC subsets remain unclear. Here we show that the Ras-PI3Kγ-Akt-mTOR signaling axis acted downstream of FLT3L signaling and was required for development of lung CD103+ DCs and, to a smaller extent, for lung CD11b+ DCs, but not related DC populations in other non-lymphoid organs. Furthermore, we show that in lymphoid organs such as the spleen, DCs depended on a similar signaling network to respond to FLT3 ligand with overlapping and partially redundant roles for kinases PI3Kγ and PI3Kδ. Thus we identified PI3Kγ as an essential organ-specific regulator of lung DC development and discovered a signaling network regulating tissue-specific DC development mediated by FLT3.
Titel: |
PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development
|
---|---|
Autor/in / Beteiligte Person: | Schneider, Christoph ; Rolink, Antonius G. ; Brocker, Thomas ; Samuel Philip Nobs ; Kopf, Manfred ; Dietrich, Maren ; Hirsch, Emilio ; University of Zurich |
Link: | |
Zeitschrift: | Immunity, Jg. 43 (2015-10-01), S. 674-689 |
Veröffentlichung: | Elsevier BV, 2015 |
Medientyp: | unknown |
ISSN: | 1074-7613 (print) |
DOI: | 10.1016/j.immuni.2015.09.006 |
Schlagwort: |
|
Sonstiges: |
|