An essential role for MEF2C in the cortical response to loss of sleep in mice
In: eLife, Jg. 9 (2020-08-01)
Online
unknown
Zugriff:
Neuronal activity and gene expression in response to the loss of sleep can provide a window into the enigma of sleep function. Sleep loss is associated with brain differential gene expression, an increase in pyramidal cell mEPSC frequency and amplitude, and a characteristic rebound and resolution of slow wave sleep-slow wave activity (SWS-SWA). However, the molecular mechanism(s) mediating the sleep-loss response are not well understood. We show that sleep-loss regulates MEF2C phosphorylation, a key mechanism regulating MEF2C transcriptional activity, and that MEF2C function in postnatal excitatory forebrain neurons is required for the biological events in response to sleep loss in C57BL/6J mice. These include altered gene expression, the increase and recovery of synaptic strength, and the rebound and resolution of SWS-SWA, which implicate MEF2C as an essential regulator of sleep function.
Titel: |
An essential role for MEF2C in the cortical response to loss of sleep in mice
|
---|---|
Autor/in / Beteiligte Person: | Kulkarni, Ashwinikumar ; Bjorness, Theresa E. ; Cowan, Christopher W. ; Rybalchenko, Volodymyr ; Konopka, Genevieve ; Bridges, Catherine ; Suzuki, Ayako ; Adam J Harrington ; Greene, Robert W. ; Takahashi, Joseph S. |
Link: | |
Zeitschrift: | eLife, Jg. 9 (2020-08-01) |
Veröffentlichung: | eLife Sciences Publications Ltd, 2020 |
Medientyp: | unknown |
Schlagwort: |
|
Sonstiges: |
|