Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion
In: eLife, Jg. 6 (2017-02-01)
Online
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Zugriff:
The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions. The parasite makes initial contact with the erythrocyte followed by dramatic deformations linked to the function of the Erythrocyte binding antigen family and P. falciparum reticulocyte binding-like families. We show EBA-175 mediates substantial changes in the deformability of erythrocytes by binding to glycophorin A and activating a phosphorylation cascade that includes erythrocyte cytoskeletal proteins resulting in changes in the viscoelastic properties of the host cell. TRPM7 kinase inhibitors FTY720 and waixenicin A block the changes in the deformability of erythrocytes and inhibit merozoite invasion by directly inhibiting the phosphorylation cascade. Therefore, binding of P. falciparum parasites to the erythrocyte directly activate a signaling pathway through a phosphorylation cascade and this alters the viscoelastic properties of the host membrane conditioning it for successful invasion. DOI: http://dx.doi.org/10.7554/eLife.21083.001
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Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion
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Autor/in / Beteiligte Person: | Tolia, Niraj H. ; F. David Horgen ; Thompson, Jennifer K. ; Fleig, Andrea ; Whitehead, Lachlan ; Tham, Wai-Hong ; Malpede, Brian M. ; Cowman, Alan F. ; O’Neill, Joseph ; Rogers, Kelly L. ; Sisquella, Xavier ; Nebl, Thomas ; Salinas, Nichole D. |
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Zeitschrift: | eLife, Jg. 6 (2017-02-01) |
Veröffentlichung: | eLife Sciences Publications, Ltd, 2017 |
Medientyp: | unknown |
ISSN: | 2050-084X (print) |
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