miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia
In: Recercat. Dipósit de la Recerca de Catalunya instname Blood Cancer Journal; (2016)
Online
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Zugriff:
The biological basis of essential thrombocythemia (ET) patients lacking known mutations is still unknown. MicroRNAs (miRNA) regulate hematopoietic differentiation and are deregulated in several hematopoietic malignancies. However, miRNA expression in ET patients has been poorly explored. We performed miRNA profiling in platelets from 19 ET patients and 10 healthy controls. Hierarchical cluster analysis showed two well-separated clusters between patients and controls, indicating that ET platelets had a characteristic 70-miRNA signature (P
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miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia
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Autor/in / Beteiligte Person: | Pons, Aina ; Bellosillo, Beatriz ; Navarro, Alfons ; Ferrer, Gerardo ; Alvarez-Larrán, Alberto ; Fernández-Rodríguez, Concepción ; Longarón, R ; Monzo, Mariano ; Camacho, Laura ; Besses, Carles ; Pairet, Silvia |
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Quelle: | Recercat. Dipósit de la Recerca de Catalunya instname Blood Cancer Journal; (2016) |
Veröffentlichung: | Nature Publishing Group, 2016 |
Medientyp: | unknown |
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