Increased Central Blood Volume: A Possible Pathophysiological Factor in Mild Low-Renin Essential Hypertension
In: Clinical Science, Jg. 51 (1976), S. 207s- (4S.)
Online
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Zugriff:
1. Patients with mild low-renin hypertension characteristically have increased central blood volume. The total blood volume is normal; the larger central blood volume reflects a shift of the blood from peripheral to central (cardiopulmonary) segments of the capacity system. 2. A relationship between central blood volume and plasma renin activity is demonstrable during tilting in normal and hypertensive subjects. In thirteen individuals there was a strong correlation between the decrease of the central blood volume and the increase in plasma renin activity in response to 12 min of 35° head-up tilt. 3. We propose that the elevated central blood volume causes greater stretch of cardiopulmonary mechanoreceptors and this in turn depresses renin release in mild low-renin hypertension.
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Increased Central Blood Volume: A Possible Pathophysiological Factor in Mild Low-Renin Essential Hypertension
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Autor/in / Beteiligte Person: | Esler, Murray D. ; Julius, Stevo |
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Zeitschrift: | Clinical Science, Jg. 51 (1976), S. 207s- (4S.) |
Veröffentlichung: | Portland Press Ltd., 1976 |
Medientyp: | unknown |
ISSN: | 0144-4107 (print) |
DOI: | 10.1042/cs051207s |
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