CD8 T cells are essential for recovery from a respiratory vaccinia virus infection
In: Journal of immunology (Baltimore, Md. : 1950), Jg. 189 (2012-07-25), Heft 5
Online
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Zugriff:
The precise immune components required for protection against a respiratory Orthopoxvirus infection, such as human smallpox or monkeypox, remain to be fully identified. In this study, we used the virulent Western Reserve strain of vaccinia virus (VACV-WR) to model a primary respiratory Orthopoxvirus infection. Naive mice infected with VACV-WR mounted an early CD8 T cell response directed against dominant and subdominant VACV-WR Ags, followed by a CD4 T cell and Ig response. In contrast to other VACV-WR infection models that highlight the critical requirement for CD4 T cells and Ig, we found that only mice deficient in CD8 T cells presented with severe cachexia, pulmonary inflammation, viral dissemination, and 100% mortality. Depletion of CD8 T cells at specified times throughout infection highlighted that they perform their critical function between days 4 and 6 postinfection and that their protective requirement is critically dictated by initial viral load and virulence. Finally, the ability of adoptively transferred naive CD8 T cells to protect RAG−/− mice against a lethal VACV-WR infection demonstrated that they are both necessary and sufficient in protecting against a primary VACV-WR infection of the respiratory tract.
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CD8 T cells are essential for recovery from a respiratory vaccinia virus infection
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Autor/in / Beteiligte Person: | Goulding, John ; Salek-Ardakani, Shahram ; Tahiliani, Vikas ; Croft, Michael ; Bogue, Rebecka |
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Zeitschrift: | Journal of immunology (Baltimore, Md. : 1950), Jg. 189 (2012-07-25), Heft 5 |
Veröffentlichung: | 2012 |
Medientyp: | unknown |
ISSN: | 1550-6606 (print) |
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