Mismatch Negativity in essential tremor: role of age at onset in pre-attentive auditory discrimination
Elsevier, 2014
Online
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Zugriff:
Objective To investigate whether pre-attentive auditory discrimination is impaired in patients with essential tremor (ET) and to evaluate the role of age at onset in this function. Methods Seventeen non-demented patients with ET and seventeen age- and sex-matched healthy controls underwent an EEG recording during a classical auditory MMN paradigm. Results MMN latency was significantly prolonged in patients with elderly-onset ET (>65 years) ( p = 0.046), while no differences emerged in either latency or amplitude between young-onset ET patients and controls. Conclusions This study represents a tentative indication of a dysfunction of auditory automatic change detection in elderly-onset ET patients, pointing to a selective attentive deficit in this subgroup of ET patients. Significance The delay in pre-attentive auditory discrimination, which affects elderly-onset ET patients alone, further supports the hypothesis that ET represents a heterogeneous family of diseases united by tremor; these diseases are characterized by cognitive differences that may range from a disturbance in a selective cognitive function, such as the automatic part of the orienting response, to more widespread and complex cognitive dysfunctions.
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Mismatch Negativity in essential tremor: role of age at onset in pre-attentive auditory discrimination
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Autor/in / Beteiligte Person: | Mannarelli, Daniela ; Pauletti, Caterina ; Vanacore, Nicola ; Locuratolo, Nicoletta ; M.C. De Lucia ; Fattapposta, Francesco |
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Veröffentlichung: | Elsevier, 2014 |
Medientyp: | unknown |
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