Effect of endothelin blockade on basal and stimulated forearm blood flow in patients with essential hypertension
In: Hypertension (Dallas, Tex. : 1979), Jg. 39 (2002-03-19), Heft 3
Online
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Zugriff:
Endothelin receptor antagonism lowers blood pressure in patients with essential hypertension, but the contribution of the endothelin system to increased vascular tone in these patients remains controversial. We used strain-gauge venous plethysmography to measure changes in basal and metabolically stimulated (peak reactive hyperemia [PRH]) forearm blood flow (FBF) induced by continuous intrabrachial infusion of SB 209670, a dual endothelin type A/endothelin type B receptor antagonist (ETRA) in 11 patients with hypertension and 12 healthy age-matched control subjects. In both groups, ETRA caused significant vasodilation (increase in FBF compared with baseline over the last 30 minutes of ETRA infusion: 75±12% in control subjects, 40±13% in hypertension patients; P
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Effect of endothelin blockade on basal and stimulated forearm blood flow in patients with essential hypertension
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Autor/in / Beteiligte Person: | Krum, Henry ; Ninio, Daniel ; Martin, Paul |
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Zeitschrift: | Hypertension (Dallas, Tex. : 1979), Jg. 39 (2002-03-19), Heft 3 |
Veröffentlichung: | 2002 |
Medientyp: | unknown |
ISSN: | 1524-4563 (print) |
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