Microalbuminuria and oxidative stress in essential hypertension
In: Journal of Internal Medicine, Jg. 255 (2004-05-01), S. 588-594
Online
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Zugriff:
Objective. To assess the relationship between microalbuminuria and oxidative stress in mononuclear peripherals cells in essential hypertension. Methods. A total of 123 hypertensive patients in absence of antihypertensive treatment were included. A 24-h ambulatory blood pressure (BP) monitoring was performed using a Spacelabs 90207 monitor, and microalbuminuria was measured in 24-h urine collections. Oxidized/reduced glutathione ratio and the content of malondialdehide and damaged base 8-oxo-2′-deoxyguanosine in genomic and mitochondrial DNA were measured in peripheral mononuclear cells. Results. In the 29 (24%) microalbuminuric subjects, the amount of reduced glutathione was significantly lower and the ratio oxidized/reduced glutathione was significantly higher than in the normoalbuminuric subjects. In contrast, the simultaneous measurement of the levels of malondialdehide and 8-oxo-2′-deoxyguanosine from both genomic and mitochondrial DNA oxidation did not achieve statistical significance between the two groups. Subjects with the highest oxidized/reduced glutathione ratio tertile showed the highest urinary albumin excretion (UAE) (P = 0.04 for trend). In a stepwise multiple regression analysis, oxidized/reduced glutathione ratio was the main significant determinant of UAE accounting for the 9% of the variance when 24-h mean BP, age, sex, body mass index, glucose and total cholesterol were included in the model. Conclusions. Oxidative stress seems to be a determinant of UAE independent of BP levels even in hypertensive subjects.
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Microalbuminuria and oxidative stress in essential hypertension
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Autor/in / Beteiligte Person: | Redon, Josep ; Giner, V. ; Sáez, Guillermo T. ; Tormos, Carmen ; Chaves, Felipe J. |
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Zeitschrift: | Journal of Internal Medicine, Jg. 255 (2004-05-01), S. 588-594 |
Veröffentlichung: | Wiley, 2004 |
Medientyp: | unknown |
ISSN: | 1365-2796 (print) ; 0954-6820 (print) |
DOI: | 10.1046/j.1365-2796.2003.01280.x |
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