Chemical composition and in vitro schistosomicidal activity of the essential oil of Plectranthus neochilus grown in Southeast Brazil
In: Chemistrybiodiversity, Jg. 8 (2011-11-16), Heft 11
Online
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Zugriff:
The chemical composition and the in vitro schistosomicidal effects of the essential oil of Plectranthus neochilus (PN-EO) grown in Southeast Brazil was studied. β-Caryophyllene (1; 28.23%), α-thujene (2; 12.22%), α-pinene (3; 12.63%), β-pinene (4; 6.19%), germacrene D (5; 5.36%), and caryophyllene oxide (6; 5.37%) were the major essential oil constituents. This chemical composition differed from that previously reported for specimens harvested in Africa. Concerning the in vitro schistosomicidal activity against adult Schistosoma mansoni worms, PN-EO was considered to be active, but less effective than the positive control praziquantel (PZQ) in terms of separation of coupled pairs, mortality, decrease in the motor activity, and tegumental alterations. However, PN-EO caused an interesting dose-dependent reduction in the number and the percentage of developed S. mansoni eggs. These results suggest that PN-EO might be very promising for the development of new schistosomicidal agents.
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Chemical composition and in vitro schistosomicidal activity of the essential oil of Plectranthus neochilus grown in Southeast Brazil
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Autor/in / Beteiligte Person: | Rodrigo Cassio Sola Veneziani ; Groppo, Milton ; Antônio Eduardo Miller Crotti ; Rodrigues, Vanderlei ; Denise Crispim Tavares ; Lizandra Guidi Magalhães ; Nathalya Isabel de Melo ; Wilson Roberto Cunha ; Pollyanna Francielli de Oliveira ; Ademar A. da Silva Filho ; Jacqueline Morais Alves ; Daniela de Paula Aguiar ; Wakabayashi, Kamila A. L. ; Caixeta, Soraya C. ; Aguiar, Gabriela P. ; Mantovani, André L. L. |
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Zeitschrift: | Chemistrybiodiversity, Jg. 8 (2011-11-16), Heft 11 |
Veröffentlichung: | 2011 |
Medientyp: | unknown |
ISSN: | 1612-1880 (print) |
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