S-palmitoylation of swine interferon-inducible transmembrane protein is essential for its anti-JEV activity
In: Virology, Jg. 548 (2020-09-01), S. 82-92
Online
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Zugriff:
Japanese encephalitis virus (JEV) is an infectious pathogen spreading in a wide range of vertebrate species. Pigs are amplifying hosts of JEV and thought to be maintained in nature predominantly by avian-mosquito cycles. In the innate immune system, interferon-inducible transmembrane protein (IFITM) is a small transmembrane protein family and has been identified as the first line of defense against a broad range of RNA virus invasion. In this paper, we found that swine IFITM (sIFITM) could restrict the replication of both JEV vaccine strain and wild strain NJ-2008. The cysteine S-palmitoylation modification of sIFITM plays important roles in their anti-JEV effects and intracellular distributions. Our findings show the anti-JEV activities of swine interferon-inducible transmembrane proteins and broaden the antiviral spectrum of IFITM protein family. The preliminary exploration of S-palmitoylation modification of sIFITM may contribute to understanding of the antiviral molecular mechanism of sIFITM.
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S-palmitoylation of swine interferon-inducible transmembrane protein is essential for its anti-JEV activity
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Autor/in / Beteiligte Person: | Li, Xiaoling ; Xue, Ji-chu ; Xu, Jun ; Zheng, Wenming ; Yin, Su-gai ; Shen, Lingyi ; Xu, Zhao |
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Zeitschrift: | Virology, Jg. 548 (2020-09-01), S. 82-92 |
Veröffentlichung: | Elsevier BV, 2020 |
Medientyp: | unknown |
ISSN: | 0042-6822 (print) |
DOI: | 10.1016/j.virol.2020.06.004 |
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