Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity
In: Journal of immunology (Baltimore, Md. : 1950), Jg. 198 (2016-10-19), Heft 2
Online
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Zugriff:
IL-10 is a pleiotropic cytokine expressed during malaria, a disease characterized by short-lived, parasite-specific Ab responses. The role of IL-10 in regulating B cell responses during malaria is not known. In this study we report that IL-10 is essential for anti-Plasmodium humoral immunity. We identify that germinal center (GC) B cell reactions, isotype-switched Ab responses, parasite control, and host survival require B cell-intrinsic IL-10 signaling. IL-10 also indirectly supports humoral immunity by suppressing excessive IFN-γ, which induces T-bet expression in B cells. Genetic ablation of either IFN-γ signaling or T-bet expression in B cells substantially enhanced GC B cell responses and anti-Plasmodium Ab production. Together, our data show that B cell-intrinsic IL-10 enhances whereas B cell-intrinsic IFN-γ and T-bet suppress GC B cell responses and anti-Plasmodium humoral immunity. These data identify critical immunoregulatory circuits in B cells that may be targeted to promote long-lived humoral immunity and resistance to malaria.
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Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity
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Autor/in / Beteiligte Person: | Zander, Ryan ; Pope, Rosemary L. ; Graham, Amy C. ; Butler, Noah S. ; Guthmiller, Jenna J. |
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Zeitschrift: | Journal of immunology (Baltimore, Md. : 1950), Jg. 198 (2016-10-19), Heft 2 |
Veröffentlichung: | 2016 |
Medientyp: | unknown |
ISSN: | 1550-6606 (print) |
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