Network Fingerprint of Stimulation‐Induced Speech Impairment in Essential Tremor
In: Annals of Neurology, Jg. 89 (2020-11-26), S. 315-326
Online
unknown
Zugriff:
OBJECTIVE This study was undertaken to gain insights into structural networks associated with stimulation-induced dysarthria (SID) and to predict stimulation-induced worsening of intelligibility in essential tremor patients with bilateral thalamic deep brain stimulation (DBS). METHODS Monopolar reviews were conducted in 14 essential tremor patients. Testing included determination of SID thresholds, intelligibility ratings, and a fast syllable repetition task. Volumes of tissue activated (VTAs) were calculated to identify discriminative fibers for stimulation-induced worsening of intelligibility in a structural connectome. The resulting fiber-based atlas structure was then validated in a leave-one-out design. RESULTS Fibers determined as discriminative for stimulation-induced worsening of intelligibility were mainly connected to the ipsilateral precentral gyrus as well as to both cerebellar hemispheres and the ipsilateral brain stem. In the thalamic area, they ran laterally to the thalamus and posteromedially to the subthalamic nucleus, in close proximity, mainly anterolaterally, to fibers beneficial for tremor control as published by Al-Fatly et al in 2019. The overlap of the respective clinical stimulation setting's VTAs with these fibers explained 62.4% (p
Titel: |
Network Fingerprint of Stimulation‐Induced Speech Impairment in Essential Tremor
|
---|---|
Autor/in / Beteiligte Person: | Mücke, Doris ; Jan Niklas Petry-Schmelzer ; Fink, Gereon R. ; Thies, Tabea ; Jergas, Hannah ; Barbe, Michael T. ; Steffen, Julia K. ; Visser-Vandewalle, Veerle ; Dafsari, Haidar S. ; Reker, Paul ; Dembek, Till A. |
Link: | |
Zeitschrift: | Annals of Neurology, Jg. 89 (2020-11-26), S. 315-326 |
Veröffentlichung: | Wiley, 2020 |
Medientyp: | unknown |
ISSN: | 1531-8249 (print) ; 0364-5134 (print) |
DOI: | 10.1002/ana.25958 |
Schlagwort: |
|
Sonstiges: |
|