Plasma enalapril levels and hormonal effects after short- and long-term administration in essential hypertension
In: British Journal of Clinical Pharmacology, Jg. 18 (1984-04-01), S. 233S- (9S.)
Online
unknown
Zugriff:
Enalapril lowers blood pressure both acutely and during long-term therapy in patients with essential hypertension. After a single 10 mg dose of enalapril a close relationship between plasma enalaprilic acid (MK-422) levels, angiotensin converting enzyme (ACE) inhibition and the acute hypotensive and hormonal effects was demonstrated. During long-term administration of enalapril, a similar relationship between the plasma enalaprilic acid level, ACE inhibition and the hypotensive effect was shown, although the dose-response curve for plasma enalaprilic acid to ACE inhibition was displaced to the right compared to the acute dose-response curve. Several weeks' administration of enalapril was needed to reach stable plateau levels of plasma enalaprilic acid and ACE inhibition. During long-term treatment with enalapril in essential hypertension, there was sustained inhibition of ACE and the associated hormonal changes.
Titel: |
Plasma enalapril levels and hormonal effects after short- and long-term administration in essential hypertension
|
---|---|
Autor/in / Beteiligte Person: | Larmour, I ; Jackson, Bruce ; Johnston, Colin I. ; Casley, D ; Cubella, R |
Link: | |
Zeitschrift: | British Journal of Clinical Pharmacology, Jg. 18 (1984-04-01), S. 233S- (9S.) |
Veröffentlichung: | Wiley, 1984 |
Medientyp: | unknown |
ISSN: | 0306-5251 (print) |
DOI: | 10.1111/j.1365-2125.1984.tb02602.x |
Schlagwort: |
|
Sonstiges: |
|