Chemical composition, antioxidant, antibacterial and cytotoxic activities of essential oil of Leontopodium leontopodioides (Willd.) Beauverd
In: Natural product research, Jg. 33 (2017-11-19), Heft 4
Online
unknown
Zugriff:
The essential oil (EO) from the aerial parts of Leontopodium leontopodioides (Willd.) Beauverd was obtained by hydrodistillation and analysed by GC–FID and GC–MS. Sixty-five compounds were identified which represent 96.2% of the total composition of the EO. The major components of the EO were palmitic acid (11.6%), n-pentadecanal (5.7%), linalool (3.8%), β-ionone (3.3%), hexahydrofarnesyl acetone (3.2%), bisabolone (3.2%) and β-caryophyllene (3.2%). The EO exhibited an excellent antibacterial activity against Staphylococcus aureus and Bacillus subtilis according to the MIC values tested by micro-dilution method. It also exhibited a significant cytotoxicity against HepG2 and MCF-7 cell lines with the IC50 values of 67.44 and 70.49 μg/mL according to the MTT assay. However, the antioxidant activity test revealed that the EO exhibited a weak DPPH radical-scavenging activity. In conclusion, the EO of L. leontopodioides could be regarded as a bioactive natural product and deserves further study for its potential therapeutic effects.
Titel: |
Chemical composition, antioxidant, antibacterial and cytotoxic activities of essential oil of Leontopodium leontopodioides (Willd.) Beauverd
|
---|---|
Autor/in / Beteiligte Person: | Ma, Qing-lin ; Gao, Yang ; Mao, Ling-Jing ; Rao, Huijuanzi |
Link: | |
Zeitschrift: | Natural product research, Jg. 33 (2017-11-19), Heft 4 |
Veröffentlichung: | 2017 |
Medientyp: | unknown |
ISSN: | 1478-6427 (print) |
Schlagwort: |
|
Sonstiges: |
|