Autistic Children Exhibit Decreased Levels of Essential Fatty Acids in Red Blood Cells

Shen, Yiping ; Shao, Hong ; et al.

In: International Journal of Molecular Sciences Volume 16 Issue 5 Pages 10061-10076 International Journal of Molecular Sciences, Jg. 16 (2015), Heft 5, S. 10061-10076

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Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFA) are essential nutrients for brain development and function. However, whether or not the levels of these fatty acids are altered in individuals with autism remains debatable. In this study, we compared the fatty acid contents between 121 autistic patients and 110 non-autistic, non-developmentally delayed controls, aged 3–17. Analysis of the fatty acid composition of red blood cell (RBC) membrane phospholipids showed that the percentage of total PUFA was lower in autistic patients than in controls

levels of n-6 arachidonic acid (AA) and n-3 docosahexaenoic acid (DHA) were particularly decreased (p <

0.001). In addition, plasma levels of the pro-inflammatory AA metabolite prostaglandin E2 (PGE2) were higher in a subset of the autistic participants (n = 20) compared to controls. Our study demonstrates an alteration in the PUFA profile and increased production of a PUFA-derived metabolite in autistic patients, supporting the hypothesis that abnormal lipid metabolism is implicated in autism.

Titel:	Autistic Children Exhibit Decreased Levels of Essential Fatty Acids in Red Blood Cells
Autor/in / Beteiligte Person:	Shen, Yiping ; Shao, Hong ; Wu, Bai-Lin ; Brigandi, Sarah A. ; Kang, Jing X. ; Qian, Steven Y.
Link:	View record at OpenAIRE (Volltext)
Zeitschrift:	International Journal of Molecular Sciences Volume 16 Issue 5 Pages 10061-10076 International Journal of Molecular Sciences, Jg. 16 (2015), Heft 5, S. 10061-10076
Veröffentlichung:	Multidisciplinary Digital Publishing Institute, 2015
Medientyp:	unknown
ISSN:	1422-0067 (print)
DOI:	10.3390/ijms160510061
Schlagwort:	Male Erythrocytes Metabolite neuroinflammation lcsh:Chemistry chemistry.chemical_compound lipid metabolism Prostaglandin E2 Child lcsh:QH301-705.5 Spectroscopy chemistry.chemical_classification Arachidonic Acid General Medicine omega-6 and omega-3 fatty acids Computer Science Applications medicine.anatomical_structure Docosahexaenoic acid Child, Preschool Arachidonic acid lipids (amino acids, peptides, and proteins) Female Polyunsaturated fatty acid medicine.drug polyunsaturated fatty acids medicine.medical_specialty Adolescent Docosahexaenoic Acids autism Biology Catalysis Article Dinoprostone Inorganic Chemistry Internal medicine medicine Humans Physical and Theoretical Chemistry Autistic Disorder Molecular Biology prostaglandin E2 Organic Chemistry Fatty acid Lipid metabolism Red blood cell Endocrinology lcsh:Biology (General) lcsh:QD1-999 chemistry Case-Control Studies
Sonstiges:	Nachgewiesen in: OpenAIRE Sprachen: English File Description: application/pdf Language: English Rights: OPEN

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