The acute airway inflammation induced by PM2.5 exposure and the treatment of essential oils in Balb/c mice
In: Scientific Reports, Jg. 7 (2017-03-01)
Online
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Zugriff:
PM2.5 is the main particulate air pollutant whose aerodynamic diameter is less than 2.5 micron. The inflammation of various respiratory diseases are associated with PM2.5 inhalation. Pro-inflammatory cytokine IL-1β generated from effected cells usually plays a crucial role in many kinds of lung inflammatory reactions. The exacerbation of Th immune responses are identified in some PM2.5 related diseases. To elucidate the underlying mechanism of PM2.5-induced acute lung inflammation, we exposed Balb/c mice to PM2.5 intratracheally and established a mice model. Acute lung inflammation and increased IL-1β expression was observed after PM2.5 instillation. Regulatory factors of IL-1β (TLR4/MyD88 signaling pathway and NLRP3 inflammasome) participated in this lung inflammatory response as well. Treatment with compound essential oils (CEOs) substantially attenuated PM2.5-induced acute lung inflammation. The decreased IL-1β and Th immune responses after CEOs treatment were significant. PM2.5 may increase the secretion of IL-1β through TLR4/MyD88 and NLRP3 pathway resulting in murine airway inflammation. CEOs could attenuate the lung inflammation by reducing IL-1β and Th immune responses in this model. This study describes a potentially important mechanism of PM2.5-induced acute lung inflammation and that may bring about novel therapies for the inflammatory diseases associated with PM2.5 inhalation.
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The acute airway inflammation induced by PM2.5 exposure and the treatment of essential oils in Balb/c mice
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Autor/in / Beteiligte Person: | Wang, Xuguang ; Ju, Wenhui ; Wang, Hetong ; Dong, Lu ; Li, Fasheng ; Song, Laiyu ; Ya, Ping ; Yang, Chun ; Zhang, Yining |
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Zeitschrift: | Scientific Reports, Jg. 7 (2017-03-01) |
Veröffentlichung: | Nature Publishing Group, 2017 |
Medientyp: | unknown |
ISSN: | 2045-2322 (print) |
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