Stat5 is essential for early B cell development but not for B cell maturation and function
In: Journal of immunology (Baltimore, Md. : 1950), Jg. 179 (2007-07-10), Heft 2
Online
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Zugriff:
The two closely related Stat5 (Stat5A and Stat5B) proteins are activated by a broad spectrum of cytokines. However, with the complication of the involvement of Stat5A/5B in stem cell function, the role of Stat5A/5B in the development and function of lymphocytes, especially B cells, is not fully understood. In this study, we demonstrated that Stat5A/5B−/− fetal liver cells had severe diminution of B cell progenitors but clearly had myeloid progenitors. Consistently, the mutant fetal liver cells could give rise to hemopoietic progenitors and myeloid cells but not B cells beyond pro-B cell progenitors in lethally irradiated wild-type or Jak3−/− mice. Deletion of Stat5A/5B in vitro directly impaired IL-7-mediated B cell expansion. Of note, reintroduction of Stat5A back into Stat5A/5B−/− fetal liver cells restored their abilities to develop B cells. Importantly, CD19-Cre-mediated deletion of Stat5A/5B in the B cell compartment specifically impaired early B cell development but not late B cell maturation. Moreover, the B cell-specific deletion of Stat5A/5B did not impair splenic B cell survival, proliferation, and Ig production. Taken together, these data demonstrate that Stat5A/5B directly control IL-7-mediated early B cell development but are not required for B cell maturation and Ig production.
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Stat5 is essential for early B cell development but not for B cell maturation and function
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Autor/in / Beteiligte Person: | Li, Geqiang ; Wen, Renren ; Wang, Demin ; Di, Lie ; Dai, Xuezhi ; Hennighausen, Lothar ; Podd, Andrew ; Bunting, Kevin D. ; Chen, Yuhong |
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Zeitschrift: | Journal of immunology (Baltimore, Md. : 1950), Jg. 179 (2007-07-10), Heft 2 |
Veröffentlichung: | 2007 |
Medientyp: | unknown |
ISSN: | 0022-1767 (print) |
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