Effect of Oral Dilevalol on Forearm Circulation in Essential Hypertension
In: Journal of Cardiovascular Pharmacology, Jg. 19 (1992-03-01), S. 367-370
Online
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Zugriff:
In 6 patients with untreated hypertension of mild or moderate degree, dilevalol was infused in the brachial artery. Doses were calculated to produce plasma levels approximating those achieved after oral dosing (0.03,0.07,0.1,0.3 rcg.kg-l.min-*) and also to produce plasma levels exceeding oral dosing (0.5, 1.0,2.0 rcgmkg-‘smin-*) without causing any blood pressure or heart rate changes. The effects of the infusion on forearm blood flow were assessed by venous occlusion plethysmography. Dllevald caused a progressive increase in flow in all subjects up to the intermediate dose given, with the effect being attenuated when the dose was increased further. Simultaneous propranolol infusion reduced the increase in flow induced by dilevalol, shifting the dikwald-induced vasodilation dose response curve to the right. lsoproterenol infusion caused a marked, dose-related increase in flow that was equally well reduced by simultaneous infusion of dilevaloi or proprandol. These results indicate that dilevalol effectively blocks peripheral vascular /? receptors in humans. The drug also acts as a partial &-receptor agonist, causing vasodilation which can be reduced by co-administration of propranold. (Am J Cardiol 1989;63:21 I-24
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Effect of Oral Dilevalol on Forearm Circulation in Essential Hypertension
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Autor/in / Beteiligte Person: | Cattaneo, Bianca M. ; Perondi, R. ; Grassi, Guido ; Zanchetti, Alberto ; Mancia, G. ; Giannattasio, Cristina ; Seravalle, Gino ; Giannattasio, C ; Seravalle, G ; Cattaneo, B ; Perondi, R ; Grassi, G ; Zanchetti, A ; Mancia, G |
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Zeitschrift: | Journal of Cardiovascular Pharmacology, Jg. 19 (1992-03-01), S. 367-370 |
Veröffentlichung: | Ovid Technologies (Wolters Kluwer Health), 1992 |
Medientyp: | unknown |
ISSN: | 0160-2446 (print) |
DOI: | 10.1097/00005344-199203000-00010 |
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