Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period
In: Journal of Experimental Medicine, Jg. 201 (2005-03-07), S. 769-777
Online
unknown
Zugriff:
Although many aspects of CD4(+)CD25(+) T regulatory (T(reg)) cell development remain largely unknown, signaling through the IL-2R represents one feature for the production of T(reg) cells. Therefore, the present study was undertaken to further define early developmental steps in the production of T(reg) cells, including a more precise view on the role of interleukin (IL)-2 in this process. After adoptive transfer of wild-type T(reg) cells into neonatal IL-2Rbeta(-/-) mice, only a small fraction of donor T(reg) cells selectively seeded the lymph node (LN). These donor T(reg) cells underwent rapid and extensive IL-2-dependent proliferation, followed by subsequent trafficking to the spleen. Thus, IL-2 is essential for T(reg) cell proliferation in neonatal LN. The number and distribution of T(reg) cells in the periphery of normal neonatal mice closely paralleled that seen for IL-2Rbeta(-/-) mice that received T(reg) cells. However, for normal neonates, blockade of IL-2 decreased T(reg) cells in both the thymus and LN. Therefore, two steps of T(reg) cell development depend upon IL-2 in neonatal mice, thymus production, and subsequent expansion in the LN.
| Titel: |
Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period
|
|---|---|
| Autor/in / Beteiligte Person: | Bayer, Allison L. ; Malek, Thomas R. ; Yu, Aixin ; Adeegbe, Dennis |
| Link: | |
| Zeitschrift: | Journal of Experimental Medicine, Jg. 201 (2005-03-07), S. 769-777 |
| Veröffentlichung: | Rockefeller University Press, 2005 |
| Medientyp: | unknown |
| ISSN: | 1540-9538 (print) ; 0022-1007 (print) |
| DOI: | 10.1084/jem.20041179 |
| Schlagwort: |
|
| Sonstiges: |
|