Serum calcium, magnesium, phosphorus, and vitamin D in benign essential blepharospasm
In: Graefe's Archive for Clinical and Experimental Ophthalmology, Jg. 258 (2020-03-31), S. 1293-1297
Online
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Zugriff:
This study aims to compare serum calcium, magnesium, phosphorus, and 25-hydroxy (OH)-vitamin D levels in patients with benign essential blepharospasm (BEB) and healthy subjects and to determine their association with disease severity and frequency. This is a prospective study conducted in a tertiary care hospital. Fifty patients (female, 39; male, 11) with BEB and 22 healthy subjects (female, 15; male, 7) included in the study. Serum calcium, magnesium, phosphorus, and vitamin D levels of BEB and healthy groups were measured. Blepharospasm severity and frequency were assessed using scales ranging from 0 to 4 by following the Jankovic Rating Scale (JRS). Though there was no significant difference regarding magnesium, phosphorus, and 25(OH)-vitamin D levels between the two groups, serum calcium levels of the BEB group were significantly lower than the control group (9.5 ± 0.4 and 9.9 ± 0.4 mg/dl, respectively; P = 0.002), although in the normal range (9–10.5 mg/dl). In the BEB group, the mean Jankovic severity and frequency scores were 3.29 ± 0.54 and 3.59 ± 0.61, respectively. There was a moderate negative correlation between serum 25(OH)-vitamin D levels and Jankovic severity score (r = − 0.332; P = 0.022). Serum calcium levels of the BEB group were significantly lower than the healthy group. Serum vitamin D levels showed a moderate negative correlation with disease severity. The role of calcium and vitamin D in the evolution of the BEB need further investigation at the cellular and anatomical levels.
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Serum calcium, magnesium, phosphorus, and vitamin D in benign essential blepharospasm
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Autor/in / Beteiligte Person: | Taskapili, Muhittin ; Zehra Karaagac Gunaydin ; Fazil, Korhan ; Senay Asik Nacaroglu ; Gamze Ozturk Karabulut ; Tunc, Ugur ; Kubra Serefoglu Cabuk |
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Zeitschrift: | Graefe's Archive for Clinical and Experimental Ophthalmology, Jg. 258 (2020-03-31), S. 1293-1297 |
Veröffentlichung: | Springer Science and Business Media LLC, 2020 |
Medientyp: | unknown |
ISSN: | 1435-702X (print) ; 0721-832X (print) |
DOI: | 10.1007/s00417-020-04650-7 |
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