Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells
In: eLife, Jg. 7 (2018-03-01)
Online
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Zugriff:
Despite marked advances in breast cancer therapy, basal-like breast cancer (BBC), an aggressive subtype of breast cancer usually lacking estrogen and progesterone receptors, remains difficult to treat. In this study, we report the identification of MELK as a novel oncogenic kinase from an in vivo tumorigenesis screen using a kinome-wide open reading frames (ORFs) library. Analysis of clinical data reveals a high level of MELK overexpression in BBC, a feature that is largely dependent on FoxM1, a master mitotic transcription factor that is also found to be highly overexpressed in BBC. Ablation of MELK selectively impairs proliferation of basal-like, but not luminal breast cancer cells both in vitro and in vivo. Mechanistically, depletion of MELK in BBC cells induces caspase-dependent cell death, preceded by defective mitosis. Finally, we find that Melk is not required for mouse development and physiology. Together, these data indicate that MELK is a normally non-essential kinase, but is critical for BBC and thus represents a promising selective therapeutic target for the most aggressive subtype of breast cancer.DOI: http://dx.doi.org/10.7554/eLife.01763.001.
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Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells
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Autor/in / Beteiligte Person: | Schlegel, Robert ; Xiang, Yi ; Mitchison, Timothy J. ; Wang, Yubao ; Tong, Haoxuan ; Von, Thanh ; Stegmeier, Frank ; Gray, Nathanael S. ; Li, Li ; Lako, Ana ; Min, Junxia ; Lim, Elgene ; Baitsch, Lukas ; Huang, Alan ; Zhao, Jean J. ; Li, Young-Mi ; Eck, Michael J. ; Choi, Christine |
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Zeitschrift: | eLife, Jg. 7 (2018-03-01) |
Veröffentlichung: | eLife Sciences Publications Ltd, 2018 |
Medientyp: | unknown |
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