Correlation between single nucleotide polymorphisms in the 3 primer untranslated region of PTX3 and the risk of essential hypertension
In: Medicine, Jg. 100 (2021-06-18), S. e25937
Online
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Zugriff:
The aim of this study was to investigate the correlation between single-nucleotide polymorphisms (SNPs) in the 3 primer of untranslated region (3’UTR) of the Pentraxin 3 (PTX3) gene and the risk of essential hypertension (EHT). PTX3 genotypes, rs2614, rs111451363, and rs73158510 locus, were found in 260 patients with EHT and 260 healthy controls. Quantitative real-time polymerase chain reaction was used to detect plasma hsa-miR-4766-5p levels. Enzyme-linked immunosorbent assay was used to detect plasma PTX3 levels. The dual-luciferase reporter assay was used to identify the binding site of hsa-miR-4766-5p to the PTX3. PTX3 rs2614 locus T allele was a high risk factor for EHT (odds ratio [OR] = 2.76, 95% confidence interval [CI]: 1.86–4.09, P
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Correlation between single nucleotide polymorphisms in the 3 primer untranslated region of PTX3 and the risk of essential hypertension
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Autor/in / Beteiligte Person: | Peng, Linlin ; Jiang, Jie ; Xiang, Huaqing ; Pan, Hongyi ; Chen, Wanwan ; Liu, Yanmei |
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Zeitschrift: | Medicine, Jg. 100 (2021-06-18), S. e25937 |
Veröffentlichung: | Ovid Technologies (Wolters Kluwer Health), 2021 |
Medientyp: | unknown |
ISSN: | 1536-5964 (print) ; 0025-7974 (print) |
DOI: | 10.1097/md.0000000000025937 |
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