Effect of chronic treatment with enalapril on glucose tolerance and serum insulin in non-insulin-resistant Japanese patients with essential hypertension
In: European journal of clinical pharmacology, Jg. 45 (1993), Heft 1
Online
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Zugriff:
The effect of enalapril, an angiotensin converting enzyme inhibitor, on glucose tolerance and serum insulin response to a glucose load has been evaluated in 8 non-obese patients (3 women and 5 men) with untreated essential hypertension (WHO Stage I or II) and without insulin resistance. Following a 2-month run-in control period, each patient received oral enalapril 10 mg once daily for 6 months, and an intravenous glucose tolerance test (IVGTT) was performed at the end of the run-in control and active treatment periods. Treatment with enalapril significantly lowered both the systolic and diastolic blood pressures. The response of plasma glucose to the IVGTT, glucose disappearance rate (k-value) and area under the serum insulin concentration time curve were comparable between the two phases. The results suggest that long-term treatment with enalapril has no effect on glucose tolerance in non-obese, non-insulin-resistant patients with mild-to-moderate essential hypertension.
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Effect of chronic treatment with enalapril on glucose tolerance and serum insulin in non-insulin-resistant Japanese patients with essential hypertension
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Autor/in / Beteiligte Person: | Kodama, T. ; Ishizaki, Takashi ; Baba, Tsuneharu |
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Zeitschrift: | European journal of clinical pharmacology, Jg. 45 (1993), Heft 1 |
Veröffentlichung: | 1993 |
Medientyp: | unknown |
ISSN: | 0031-6970 (print) |
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