An RNA Ligase Essential for RNA Editing and Survival of the Bloodstream Form ofTrypanosoma brucei
In: Science, Jg. 291 (2001-03-16), S. 2159-2162
Online
unknown
Zugriff:
RNA editing in trypanosomes occurs by a series of enzymatic steps that are catalyzed by a macromolecular complex. The TbMP52 protein is shown to be a component of this complex, to have RNA ligase activity, and to be one of two adenylatable proteins in the complex. Regulated repression ofTbMP52blocks editing, which shows that it is a functional component of the editing complex. This repression is lethal in bloodforms of the parasite, indicating that editing is essential in the mammalian stage of the life cycle. The editing complex, which is present in all kinetoplastid parasites, may thus be a chemotherapeutic target.
Titel: |
An RNA Ligase Essential for RNA Editing and Survival of the Bloodstream Form ofTrypanosoma brucei
|
---|---|
Autor/in / Beteiligte Person: | Stuart, Kenneth ; Igo, Robert P. ; Panicucci, Brian ; Salavati, Reza ; Panigrahi, Aswini K. ; Schnaufer, Achim |
Link: | |
Zeitschrift: | Science, Jg. 291 (2001-03-16), S. 2159-2162 |
Veröffentlichung: | American Association for the Advancement of Science (AAAS), 2001 |
Medientyp: | unknown |
ISSN: | 1095-9203 (print) ; 0036-8075 (print) |
DOI: | 10.1126/science.1058955 |
Schlagwort: |
|
Sonstiges: |
|