Endothelin-1-induced vasopressor responses in essential hypertension
In: Hypertension (Dallas, Tex. : 1979), Jg. 30 (1997-07-01), Heft 1 Pt 1
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Zugriff:
Abstract The potential role of endothelin-1 (ET-1) in essential hypertension in humans is still subject to debate. We recently reported strong sodium retention and renal vasoconstriction during pathophysiological increments in plasma ET-1. Apart from this vasoconstrictor action, ET-1 also has mitogenic properties that play a role in the pathophysiology of hypertension. On the other hand, some data refute an important role of ET-1 in hypertension. We therefore investigated in nine subjects with essential hypertension the constrictor actions of ET-1 by challenging these subjects with a systemic infusion of ET-1 (0.5 ng/kg per minute for 60 minutes, then 1.0 ng/kg per minute for 60 minutes, and finally 2.0 ng/kg per minute for 60 minutes). Furthermore, we studied whether these effects of ET-1 could be modulated by oral use of the angiotensin-converting enzyme inhibitor enalapril (20 mg BID) or the calcium channel blocker nifedipine (60 mg OD). ET-1 infusion increased plasma ET-1 levels from 2.5±0.4 to 11.6±1.0 pmol/L ( P P P P P P P P P
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Endothelin-1-induced vasopressor responses in essential hypertension
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Autor/in / Beteiligte Person: | Koomans, Hein A. ; Kaasjager, Karin A. H. ; Rabelink, Ton J. |
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Zeitschrift: | Hypertension (Dallas, Tex. : 1979), Jg. 30 (1997-07-01), Heft 1 Pt 1 |
Veröffentlichung: | 1997 |
Medientyp: | unknown |
ISSN: | 0194-911X (print) |
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