A simplified screening test for differentiating primary aldosteronism from essential hypertension with low plasma renin activity
In: Japanese Circulation Journal, Jg. 44 (1980), S. 719-725
Online
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Zugriff:
A simplified screening test for differentiating primary aldosteronism (PA) from low renin essential hypertension (LREH) is presented. Nine patients with LREH and 5 patients with PA due to adrenal adenoma were studied. In the patients with LREH, the levels of plasma renin activity (PRA) before and after treatment with furosemide (0.7 mg/kg, i.v.) and a 2-hour ambulation under treatment with dexamethasone (1.0 mg) (dexamethasone + furosemide test) increased briskly, compared to the levels of PRA before and after treatment with furosemide (0.7 mg/kg, i.v.) and a 2-hour ambulation (furosemide test). In patients with PA, there was no significant difference between the mean levels before the furosemide test and before the dexamethasone + furosemide test, or between the mean levels after the furosemide test and after the dexamethasone + furosemide test. These results suggest that the suppression of PRA in patients with LREH may be related to a factor controlled by dexamethasone. It is concluded that the dexamethasone + furosemide test is useful for differentiating PA due to adenoma from LREH.
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A simplified screening test for differentiating primary aldosteronism from essential hypertension with low plasma renin activity
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Autor/in / Beteiligte Person: | Izumi, Yoichi ; Tsuchiya, Makoto ; Inoue, Tsuyoshi ; Watanabe, Hideto ; Hatano, Michinobu ; Shiratsuchi, Toshiaki ; Ueda, Yasuhisa ; Honda, Masanobu |
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Zeitschrift: | Japanese Circulation Journal, Jg. 44 (1980), S. 719-725 |
Veröffentlichung: | Japanese Circulation Society, 1980 |
Medientyp: | unknown |
ISSN: | 1347-4839 (print) ; 0047-1828 (print) |
DOI: | 10.1253/jcj.44.719 |
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