Wall teichoic acid is an essential component of Staphylococcus aureus for the induction of human dendritic cell maturation
In: Molecular Immunology, Jg. 81 (2017), S. 135-142
Online
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Zugriff:
Staphylococcus aureus is a Gram-positive pathogen that can cause chronic skin inflammation, pneumonia, and septic shock. The immunomodulatory functions of wall teichoic acid (WTA), a glycopolymer abundantly expressed on the Gram-positive bacterial cell wall, are poorly understood. Here, we investigated the role of WTA in the phenotypic and functional activation of human monocyte-derived dendritic cells (DCs) treated with ethanol-killed S. aureus. WTA-deficient S. aureus mutant (ΔtagO) exhibited attenuated binding and internalization to DCs compared to the wild-type. ΔtagO induced lower expression of maturation markers on and cytokines in DCs than the wild-type S. aureus. Furthermore, autologous human peripheral blood mononuclear cells cocultured with ΔtagO-treated DCs exhibited a marked reduction in T cell proliferative activity, the expression of activation markers, and the production of cytokines compared to the wild-type S. aureus-stimulated DCs. Collectively, these results suggest that WTA is an important cell wall component of S. aureus for the induction of DC maturation and activation.
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Wall teichoic acid is an essential component of Staphylococcus aureus for the induction of human dendritic cell maturation
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Autor/in / Beteiligte Person: | Eun Byeol Ko ; Seung Hyun Han ; Yun, Cheol-Heui ; Sun Kyung Kim ; Sung Jun Hong |
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Zeitschrift: | Molecular Immunology, Jg. 81 (2017), S. 135-142 |
Veröffentlichung: | Elsevier BV, 2017 |
Medientyp: | unknown |
ISSN: | 0161-5890 (print) |
DOI: | 10.1016/j.molimm.2016.12.008 |
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