Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts ofSeseli pallasii<scp>Besser</scp>(Apiaceae)
In: Chemistry & Biodiversity, Jg. 14 (2017-04-17), S. e1600407
Online
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Zugriff:
The present paper describes environmental and seasonal-related chemical composition variations, vasorelaxant and angiotensin I-converting enzyme (ACE) activities of essential oil from aerial parts of Seseli pallasii BESSER. The composition was analyzed by GC and GC/MS. Monoterpenes were found to be the most abundant chemical class with alpha-pinene (42.7 - 48.2%) as the most prevalent component. Seseli pallasi essential oil relaxed isolated endothelium-intact mesenteric arteries rings precontracted with phenylephrine with IC50 = 3.10 nl/ml (IC50 = 2.70 mu g/ml). Also, S. pallasii essential oil was found to exhibit a dose-dependent ACE inhibitory activity with an IC50 value of 0.33 mg/ml. In silico evaluation of ACE inhibitory activity of the individual components showed that spathulenol exhibited the best binding affinity with ACE, and the lowest binding energy of -7.5 kcal/mol. The results suggested that combination of vasorelaxing and ACE inhibitory effects of the analyzed S. pallasii essential oil might have the potential therapeutic significance in hypertension.
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Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts ofSeseli pallasii<scp>Besser</scp>(Apiaceae)
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Autor/in / Beteiligte Person: | Milovanović, Slobodan ; Lakušić, Branislava ; Drakul, Dragana ; Kundaković, Tatjana ; Suručić, Relja ; Kovacevic, Nada |
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Zeitschrift: | Chemistry & Biodiversity, Jg. 14 (2017-04-17), S. e1600407 |
Veröffentlichung: | Wiley, 2017 |
Medientyp: | unknown |
ISSN: | 1612-1872 (print) |
DOI: | 10.1002/cbdv.201600407 |
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