BCR rearrangement in apparent essential thrombocythaemia
In: British Journal of Haematology, Jg. 85 (2008-03-12), S. 625-626
Online
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Zugriff:
The presence of the Philadelphia chromosome is a major determinant of the prognosis of patients with myeloproliferative disorders. We describe a case of apparent essential thrombocythaemia in whom cytogenetic analysis was normal. However, the presence of basophilia, the absence of abnormal megakaryocytes in a trephine biopsy and the female sex of the patient prompted Southern analysis of peripheral granulocyte DNA. This revealed a BCR rearrangement and the patient has therefore undergone allogeneic bone marrow transplantation. This case emphasizes the importance of both cytogenetic and molecular analysis of patients with apparent essential thrombocythaemia.
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BCR rearrangement in apparent essential thrombocythaemia
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Autor/in / Beteiligte Person: | Marcus, Robert ; Bloxham, David ; Green, Anthony R. ; Nacheva, EP ; Richards, E. M. |
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Zeitschrift: | British Journal of Haematology, Jg. 85 (2008-03-12), S. 625-626 |
Veröffentlichung: | Wiley, 2008 |
Medientyp: | unknown |
ISSN: | 0007-1048 (print) |
DOI: | 10.1111/j.1365-2141.1993.tb03361.x |
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