Antihypertensive effect of diacetolol in essential hypertension
In: British Journal of Clinical Pharmacology, Jg. 13 (1982-04-01), S. 533-537
Online
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Zugriff:
1 Diacetolol is the N-acetylated metabolite of acebutolol and possesses beta-adrenergic receptor blocking properties. 2 Its antihypertensive action was assessed in accordance with a double-blind randomised cross-over scheme in 17 patients with moderate essential hypertension previously well controlled with acebutolol. 3 Significant reductions in lying mean arterial blood pressure were observed with daily doses of 200 mg (- 9%), 400 mg (- 10%) and 800 mg (- 14%), and were associated with significant decreases in heart rate and plasma renin activity. 4 The diacetolol mean plasma level measured 8 to 10 h after drug ingestion was proportional to the dose (207 +/- 27, 394 +/- 63 and 823 +/- 135 ng/ml for respectively 200, 400 and 800 mg/day).
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Antihypertensive effect of diacetolol in essential hypertension
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Autor/in / Beteiligte Person: | Ménard, Joël ; Thibonnier, M ; Flabeau, C ; Pasquier, P ; Flouvat, B ; Roux, A ; Thouvenin, M |
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Zeitschrift: | British Journal of Clinical Pharmacology, Jg. 13 (1982-04-01), S. 533-537 |
Veröffentlichung: | Wiley, 1982 |
Medientyp: | unknown |
ISSN: | 0306-5251 (print) |
DOI: | 10.1111/j.1365-2125.1982.tb01417.x |
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