JAK2 V617F Mutation Identifies a Biologically Distinct Subtype of Essential Thrombocythemia Which Resembles Polycythemia Vera
In: Blood, Jg. 106 (2005-11-16), S. 253-253
Online
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Zugriff:
An acquired V617F mutation in JAK2 occurs in most patients with polycythemia vera (PV) but only half of those with essential thrombocythemia (ET) and idiopathic myelofibrosis. It is not known whether mutation-bearing patients are biologically distinct from those lacking the mutation, or why the same mutation is associated with different phenotypes. Two sensitive PCR-based methods were used to assess the JAK2 mutation status of 806 patients with ET, including 776 from the MRC PT-1 trial and two other prospective studies. The combined cohort provides a unique resource for studying ET, particularly in view of its large size, centralized review of end-points and comprehensive follow-up. The involvement of a large number of secondary and tertiary centers, together with the inclusion of patients in all risk categories, suggest the results are of general relevance. JAK2 mutation status divided the cohort into two distinct subgroups. Mutation-positive patients (53.4%) displayed multiple features resembling PV, with significantly increased hemoglobin levels (p JAK2 mutation status defines two biologically distinct subgroups of ET with differences in presentation, outcome and response to therapy. Our results suggest a model in which V617F-positive ET and PV form a continuum, with the degree of erythrocytosis determined by physiological or genetic modifiers, including iron stores, epo homeostasis, gender and V617F-homozygosity. This concept has major implications for the classification, diagnosis and management of MPDs.
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JAK2 V617F Mutation Identifies a Biologically Distinct Subtype of Essential Thrombocythemia Which Resembles Polycythemia Vera
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Autor/in / Beteiligte Person: | Smith, Steve ; Joanne T Marsden ; East, Clare L. ; Scott, Linda M. ; Bench, Anthony J. ; Green, Anthony R. ; Reilly, John T. ; Vassiliou, George S. ; Boyd, Elaine M. ; Scott, Michael A. ; Erber, Wendy N. ; Buck, Georgina ; Campbell, Peter J. ; Wilkins, Bridget S. ; Bareford, David ; Duffy, Audrey ; Milligan, Don ; Harrison, Claire N. ; Wheatley, Keith |
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Zeitschrift: | Blood, Jg. 106 (2005-11-16), S. 253-253 |
Veröffentlichung: | American Society of Hematology, 2005 |
Medientyp: | unknown |
ISSN: | 1528-0020 (print) ; 0006-4971 (print) |
DOI: | 10.1182/blood.v106.11.253.253 |
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