C-Reactive Protein, Left Ventricular Mass Index, and Risk of Cardiovascular Disease in Essential Hypertension
In: Hypertension Research, Jg. 30 (2007), S. 1177-1185
Online
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Zugriff:
We examined the association between C-reactive protein (CRP) and left ventricular mass index (LVMI), and investigated prospectively the incidence of cardiovascular disease (CVD) in asymptomatic subjects with essential hypertension. A total of 629 subjects (mean age 62 years, 51% female) free of prior CVD were included in this study. In cross-sectional analysis at baseline, patients were divided into three groups according to serum CRP levels:1, 1 to 2, and2 mg/L. In multivariate analysis, LVMI increased in a stepwise fashion with increasing CRP levels in both men (127.2+/-2.9, 138.7+/-4.1, 141.8+/-3.5 g/m(2), respectively; F=6.85, p=0.001) and women (119.5+/-3.6, 129.2+/-4.9, 130.2+/-4.8 g/m(2); F=4.23, p=0.031). During follow-up (mean 32 months), 52 subjects (19 female) developed CVD. Kaplan-Meier analysis with log-rank tests showed a significantly poorer event-free survival rate in the group with elevated CRP levels (or =1 mg/L) (chi(2)=8.22, p0.01) and that with left ventricular hypertrophy (LVH) (chi(2)=19.91, p0.01). When participants were divided into four groups on the basis of CRP level (1 oror =1 mg/L) and the absence or presence of LVH, the group with LVH/CRPor =1 mg/L showed markedly poorer event-free survival (chi(2)=28.02, p0.01), and the adjusted hazard ratio by multivariate Cox regression analysis was 2.65 (95% confidence interval [CI]=1.55-5.46, p0.01). In the subgroup with LVH (n=362), a significantly lower event-free survival rate of CVD was also observed in the group with CRPor =1 mg/L (hazard ratio [HR] 1.37, 95% CI: 1.02-1.85, p=0.025). Our findings demonstrate that the CRP level is independently associated with LVMI, and suggest that measurement of CRP may provide clinically important prognostic information to supplement LVH.
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C-Reactive Protein, Left Ventricular Mass Index, and Risk of Cardiovascular Disease in Essential Hypertension
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Autor/in / Beteiligte Person: | Horio, Takeshi ; Kamide, Kei ; Kawano, Yuhei ; Ogihara, Toshio ; Rakugi, Hiromi ; Iwashima, Yoshio |
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Zeitschrift: | Hypertension Research, Jg. 30 (2007), S. 1177-1185 |
Veröffentlichung: | Japanese Society of Hypertension, 2007 |
Medientyp: | unknown |
ISSN: | 1348-4214 (print) ; 0916-9636 (print) |
DOI: | 10.1291/hypres.30.1177 |
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