Clinical Characteristics of Parkinson’s Disease Developed from Essential Tremor
In: Journal of Parkinson's Disease, Jg. 7 (2017-05-16), S. 369-376
Online
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Zugriff:
Background Recent genetic and epidemiological studies have shown that there is a link between essential tremor and Parkinson's disease (PD). However, there is a lack of data about the clinical features of PD developed from essential tremor. Objective To explore and describe the clinical characteristics of Parkinson's disease developed from essential tremor (ET-PD). Methods Twenty-five ET-PD patients and 124 IPD controls were enrolled according to each criterion. Motor and non-motor features and dopamine transporter uptake were compared between the two groups. Results Rest and action tremors were more severe in ET-PD patients than in IPD patients. In addition, tremor disorder of first-degree relatives occurred more frequently in the ET-PD group than in the IPD group. A comparison between cases with ET-PD and IPD was not significant for striatal dopamine transporter uptake. Among the non-motor features, sleep disorder frequency, especially rapid-eye-movement sleep behavioral disorder, were lower in patients with ET-PD than in those with IPD, and smell identification test scores were higher in patients with ET-PD than in those with IPD. The prevalence of other non-motor symptoms did not differ between the two groups. Conclusion This is the first comparison of motor and non-motor features between ET-PD and IPD. ET-PD and IPD have different characteristic motor and non-motor features from the nosologic perspective.
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Clinical Characteristics of Parkinson’s Disease Developed from Essential Tremor
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Autor/in / Beteiligte Person: | Lee, Sihoon ; Lee, Kwang-Soo ; Park, Jeong-Wook ; Oh, Yoon-Sang ; An, Jae-Young ; Kim, Joong-Seok ; Song, In-Uk ; Ryu, Dong-Woo |
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Zeitschrift: | Journal of Parkinson's Disease, Jg. 7 (2017-05-16), S. 369-376 |
Veröffentlichung: | IOS Press, 2017 |
Medientyp: | unknown |
ISSN: | 1877-718X (print) ; 1877-7171 (print) |
DOI: | 10.3233/jpd-160992 |
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