The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
In: Communications Biology, Jg. 4 (2021), Heft 1, S. 1-14
Online
unknown
Zugriff:
T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. In the absence of the eukaryotic type II chaperonin complex, CCT, T cell activation induced changes in the proteome are compromised including the formation of nuclear actin filaments and the formation of a normal cell stress response. Consequently, thymocyte maturation and selection, and T cell homeostatic maintenance and receptor-mediated activation are severely impaired. In the absence of CCT-controlled protein folding, Th2 polarization diverges from normal differentiation with paradoxical continued IFN-γ expression. As a result, CCT-deficient T cells fail to generate an efficient immune protection against helminths as they are unable to sustain a coordinated recruitment of the innate and adaptive immune systems. These findings thus demonstrate that normal T cell biology is critically dependent on CCT-controlled proteostasis and that its absence is incompatible with protective immunity.
Communications Biology, 4 (1)
ISSN:2399-3642
Titel: |
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
|
---|---|
Autor/in / Beteiligte Person: | Mpj., White ; Deadman, Mary E. ; Howie, Duncan ; Rota, Ioanna A. ; Fischer, Roman ; Trede, Nikolaus S. ; Handel, Adam E. ; Holländer, Georg A. ; Bergithe E Oftedal ; Kessler, Benedikt M. ; Prevot, N ; Maizels, Rick M. ; Davis, Simon J. ; Sezgin, Erdinc ; Maio, Stefano |
Link: | |
Zeitschrift: | Communications Biology, Jg. 4 (2021), Heft 1, S. 1-14 |
Veröffentlichung: | Springer Nature, 2021 |
Medientyp: | unknown |
ISSN: | 2399-3642 (print) |
Schlagwort: |
|
Sonstiges: |
|