Human β2-adrenergic receptor polymorphisms: No association with essential hypertension in black or white Americans
In: Clinical Pharmacology & Therapeutics, Jg. 67 (2000-06-01), S. 670-675
Online
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Zugriff:
Background and Objectives The most common polymorphisms of the human β2-adrenergic receptor-Arg16Gly and Gln27Glu-are associated with alterations in β2-adrenergic receptor responses, both in vitro and in vivo. β2-Adrenergic receptor–mediated vascular responses are affected by ethnicity, blood pressure, and genotype. We tested the hypothesis that these two common β2-adrenergic receptor genetic variants are associated with essential hypertension in black or white Americans. Subjects and Methods In a population-based case-control association study, the relationship between β2-adrenergic receptor genotypes and hypertension was examined in 307 normotensive subjects (128 black and 179 white) and 356 hypertensive subjects (155 black and 201 white). A polymerase chain reaction–based single-stranded conformational polymorphism method with direct sequencing of the bands of interest was used to detect the two frequently occurring β2-adrenergic receptor variants (Arg16Gly, Gln27Glu). Results No significant differences in the distributions of alleles and genotypes of the tested β2-adrenergic receptor variants were found between normotensive and hypertensive groups from either black or white Americans (all P > .05). There was a marked interethnic difference in the frequency of the Gln27Glu β2-adrenergic receptor polymorphism in both normotensive and hypertensive subjects. In normotensive white subjects, the variant Glu27 allele (35.2% versus 18.0%; P < .0001) and Glu27 homozygous genotype (14.0% versus 4.7%; P < .01) were more common than in black subjects. Similarly, in hypertensive white subjects, the variant Glu27 allele (35.8% versus 18.4%; P < .0001) and the Glu27 homozygous genotype (15.9% versus 2.6%; P < .0001) were more common than in black subjects. Conclusions These data suggest that although there are marked ethnic differences in their distribution, the common genetic polymorphisms of the human β2-adrenergic receptor gene do not cosegregate with the presence of hypertension in either black or white Americans. Clinical Pharmacology & Therapeutics (2000) 67, 670–675; doi: 10.1067/mcp.2000.106293
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Human β2-adrenergic receptor polymorphisms: No association with essential hypertension in black or white Americans
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Autor/in / Beteiligte Person: | Gainer, James V. ; Goree, Robert E. ; Dishy, Victor ; Sofowora, Gbenga G. ; Hong Guang Xie ; Wood, Alastair J. J. ; Haines, Jonathan L. ; Brown, Nancy J. ; Kim, Richard B. ; C. Michael Stein |
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Zeitschrift: | Clinical Pharmacology & Therapeutics, Jg. 67 (2000-06-01), S. 670-675 |
Veröffentlichung: | Springer Science and Business Media LLC, 2000 |
Medientyp: | unknown |
ISSN: | 0009-9236 (print) |
DOI: | 10.1067/mcp.2000.106293 |
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