Interaction Between Essential (Zn) and Toxic (Cd) Elements in Different Stages of Female Breast Cancer Patients, Resident in Different Cities of Sindh, Pakistan
In: Biological Trace Element Research, Jg. 200 (2021-05-31), S. 1117-1126
Online
unknown
Zugriff:
Breast cancer is the most familiar solid tumor analyzed in women. Trace elements have critical roles in cancer biology. In this research, the relationship between carcinogenic element, cadmium (Cd), and anti-carcinogenic elements, zinc (Zn), in the scalp hair and blood samples of four stages of female breast cancer patients was studied. We have determined the essential trace (Zn) and toxic (Cd) elements, in biological samples (scalp hair and blood) of female breast cancer (n = 96 age ranging 22–35 years), residents of various cities of Pakistan. For comparative study, the biological samples of age-matched healthy (referent) subjects (n = 115) were also analyzed for selected metals. The validity and accuracy of the methodology were checked by using certified reference materials of biological referent materials (human hair (BCR 397) and ClinCheck lyophilized blood). The mean concentrations of Cd were found to be 3- to fourfold significantly higher in the scalp hair and blood samples of female breast patients as compared to referents, while reverse results were obtained in the case of Zn (p > 0.001). The observed data shows the significant effect of carcinogenic (Cd) and their balance towards the anti-carcinogenic (Zn) in humans.
Titel: |
Interaction Between Essential (Zn) and Toxic (Cd) Elements in Different Stages of Female Breast Cancer Patients, Resident in Different Cities of Sindh, Pakistan
|
---|---|
Autor/in / Beteiligte Person: | Farah Naz Talpur ; Tasneen Gul Kazi ; Jameel Ahmed Baig ; Ghulam Qadir Chanihoon ; Hassan Imran Afridi |
Link: | |
Zeitschrift: | Biological Trace Element Research, Jg. 200 (2021-05-31), S. 1117-1126 |
Veröffentlichung: | Springer Science and Business Media LLC, 2021 |
Medientyp: | unknown |
ISSN: | 1559-0720 (print) ; 0163-4984 (print) |
DOI: | 10.1007/s12011-021-02757-4 |
Schlagwort: |
|
Sonstiges: |
|