Heparin-induced thrombocytopenia leading to a diagnosis of essential thrombocythemia
In: International Journal of Laboratory Hematology International Journal of Laboratory Hematology, Wiley, 2021, 43 (4), pp.O193-O196. ⟨10.1111/ijlh.13507⟩ International Journal of Laboratory Hematology, 2021, 43 (4), pp.O193-O196. ⟨10.1111/ijlh.13507⟩; (2021-08-01)
Online
unknown
Zugriff:
International audience; Essential thrombocythemia (ET) belongs to the “BCR-ABL-negative” subcategory of myeloproliferative neoplasms (MPN) along with polycythemia vera (PV) and primary myelofibrosis (PM). Various recurrent molecular alterations have been described in classical MPN, such as JAK2 V617F, MPL W515L/K mutations, and deletion or insertions in the calreticulin (CALR) gene.1 MPN are known for high incidence of thrombotic complications, with a predominance of arterial rather than venous events (16.2% vs 6.2%). Indeed, the prevalence of overall thrombosis has been described in 28.6%, 20.7%, and 9.5% of patients with PV, ET, and PM, respectively.2 In addition to the traditional risk factors of thrombosis, blood cells count, mutational profile, chronic inflammation, and abnormal cell adhesion appear to be specific risk factors of thrombosis in MPN-patients.3 The classical initial treatment of these thrombotic complications includes unfractionated heparin (UFH).
| Titel: |
Heparin-induced thrombocytopenia leading to a diagnosis of essential thrombocythemia
|
|---|---|
| Autor/in / Beteiligte Person: | Bernard, Marc ; Nedelec-Gac, Fabienne ; Mabo, Philippe ; Valaize, Jessica ; Gueret, Pierre ; Gouin-Thibault, Isabelle ; Pontis, Adeline ; Kerleveo, Martin ; Centre d'Investigation Clinique [Rennes] (CIC) ; Université de Rennes 1 (UR1) ; Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM) ; CHU Pontchaillou [Rennes] ; Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Jonchère, Laurent |
| Link: | |
| Quelle: | International Journal of Laboratory Hematology International Journal of Laboratory Hematology, Wiley, 2021, 43 (4), pp.O193-O196. ⟨10.1111/ijlh.13507⟩ International Journal of Laboratory Hematology, 2021, 43 (4), pp.O193-O196. ⟨10.1111/ijlh.13507⟩; (2021-08-01) |
| Veröffentlichung: | HAL CCSD, 2021 |
| Medientyp: | unknown |
| ISSN: | 1751-5521 (print) ; 1365-2257 (print) |
| Schlagwort: |
|
| Sonstiges: |
|