Effects of combined statin and ACE inhibitor therapy on endothelial function and blood pressure in essential hypertension - a randomised double-blind, placebo controlled crossover study
In: Journal of the Renin-Angiotensin-Aldosterone System, Jg. 20 (2019-09-01)
Online
unknown
Zugriff:
Background: The aim of this study was to compare the influence of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on endothelial function and blood pressure in patients with essential hypertension on long-term angiotensin-converting enzyme inhibitor therapy. Method: The study was designed as a prospective, double-blind, randomised, placebo controlled, crossover clinical trial. Twenty patients with essential hypertension were treated with an angiotensin-converting enzyme inhibitor; the control group included 10 healthy subjects. Hypertensive patients received in random order 80 mg of fluvastatin daily or placebo for 6 weeks. The following parameters were assessed at baseline and after each treatment period: serum lipids, flow-mediated vasodilation, activity of von Willebrand factor, concentration of vascular endothelial growth factor, C-reactive protein and 24-hour blood pressure profile. Results: Hypertensive patients did not differ from healthy subjects with respect to age, body mass and biochemical parameters, with the exception of C-reactive protein, which was higher in hypertensive patients ( P=0.02). After statin therapy, low-density lipoprotein cholesterol ( PConclusions: Statins added to angiotensin-converting enzyme inhibitors may improve endothelial function and ameliorate inflammation independently of blood pressure.
Titel: |
Effects of combined statin and ACE inhibitor therapy on endothelial function and blood pressure in essential hypertension - a randomised double-blind, placebo controlled crossover study
|
---|---|
Autor/in / Beteiligte Person: | Nowicki, Michał ; Ruszkowski, Piotr ; Masajtis-Zagajewska, Anna |
Link: | |
Zeitschrift: | Journal of the Renin-Angiotensin-Aldosterone System, Jg. 20 (2019-09-01) |
Veröffentlichung: | Hindawi - SAGE Publishing, 2019 |
Medientyp: | unknown |
ISSN: | 1752-8976 (print) |
Schlagwort: |
|
Sonstiges: |
|