Antimicrobial Activity and Synergy Investigation of Hypericum scabrum Essential Oil with Antifungal Drugs
In: Molecules, Jg. 26 (2021-10-01), Heft 6545
Online
unknown
Zugriff:
The chemical composition of Lebanese Hypericum scabrum essential oil (EO) was analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GG-MS). Its antimicrobial activity was evaluated by determining its minimal inhibitory concentrations (MICs) against a Gram-negative and a Gram-positive bacterium, one yeast, and five dermatophytes. H. scabrum EO was most active on filamentous fungi (MIC values of 32–64 µg/mL). Synergy within the oil was investigated by testing each of the following major components on Trichophyton rubrum: α-pinene, limonene, myrcene, β-pinene and nonane, as well as a reconstructed EO. The antifungal activity of the natural oil could not be reached, meaning that its activity might be due, in part, to minor constituent(s). The interactions between H. scabrum EO and commercially available antifungals were assessed by the checkerboard test. A synergistic effect was revealed in the combination of the EO with amphotericin B.
Titel: |
Antimicrobial Activity and Synergy Investigation of Hypericum scabrum Essential Oil with Antifungal Drugs
|
---|---|
Autor/in / Beteiligte Person: | Ouaini, Naim ; Eparvier, Véronique ; Fahed, Layal ; Stien, Didier ; Vitalini, Sara ; Iriti, Marcello ; Marc El Beyrouthy ; Libanaise, Université ; Institut de Chimie des Substances Naturelles (ICSN) ; Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) ; Holy-Spirit University of Kaslik [Jounieh] ; Laboratoire de Biochimie et de Biologie Moléculaire (Université d'Abomey Calavi, Cotonou, Bénin) (LBBM) ; University of Abomey Calavi (UAC) ; Observatoire océanologique de Banyuls (OOB) ; Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ; Università degli Studi di Milano [Milano] (UNIMI) ; Università degli studi di Napoli Federico, II |
Link: | |
Zeitschrift: | Molecules, Jg. 26 (2021-10-01), Heft 6545 |
Veröffentlichung: | MDPI AG, 2021 |
Medientyp: | unknown |
ISSN: | 1420-3049 (print) |
Schlagwort: |
|
Sonstiges: |
|