An Essential Role for BLNK in Human B Cell Development
In: Science, Jg. 286 (1999-12-03), S. 1954-1957
Online
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Zugriff:
The signal transduction events that control the progenitor B cell (pro-B cell) to precursor B cell (pre-B cell) transition have not been well delineated. In evaluating patients with absent B cells, a male with a homozygous splice defect in the cytoplasmic adapter protein BLNK (B cell linker protein) was identified. Although this patient had normal numbers of pro-B cells, he had no pre-B cells or mature B cells, indicating that BLNK plays a critical role in orchestrating the pro-B cell to pre-B cell transition. The immune system and overall growth and development were otherwise normal in this patient, suggesting that BLNK function is highly specific.
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An Essential Role for BLNK in Human B Cell Development
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Autor/in / Beteiligte Person: | Rohrer, Jurg ; Chan, Andrew C. ; Lederman, Howard M. ; Minegishi, Yoshiyuki ; Campana, Dario ; Mary Ellen Conley ; Coustan-Smith, Elaine ; Pappu, Rajita |
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Zeitschrift: | Science, Jg. 286 (1999-12-03), S. 1954-1957 |
Veröffentlichung: | American Association for the Advancement of Science (AAAS), 1999 |
Medientyp: | unknown |
ISSN: | 1095-9203 (print) ; 0036-8075 (print) |
DOI: | 10.1126/science.286.5446.1954 |
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