Essential Polyunsaturated Fatty Acids in Blood from Patients with and without Catheter-Proven Coronary Artery Disease
In: International Journal of Molecular Sciences, Jg. 23 (2022-01-11), Heft 766, p 766, S. 766-766
Online
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Zugriff:
Coronary artery disease (CAD) is the leading cause of death worldwide. Statins reduce morbidity and mortality of CAD. Intake of n-3 polyunsaturated fatty acid (n-3 PUFAs), particularly eicosapentaenoic acid (EPA), is associated with reduced morbidity and mortality in patients with CAD. Previous data indicate that a higher conversion of precursor fatty acids (FAs) to arachidonic acid (AA) is associated with increased CAD prevalence. Our study explored the FA composition in blood to assess n-3 PUFA levels from patients with and without CAD. We analyzed blood samples from 273 patients undergoing cardiac catheterization. Patients were stratified according to clinically relevant CAD (n = 192) and those without (n = 81). FA analysis in full blood was performed by gas chromatography. Indicating increased formation of AA from precursors, the ratio of dihomo-gamma-linolenic acid (DGLA) to AA, the delta-5 desaturase index (D5D index) was higher in CAD patients. CAD patients had significantly lower levels of omega-6 polyunsaturated FAs (n-6 PUFA) and n-3 PUFA, particularly EPA, in the blood. Thus, our study supports a role of increased EPA levels for cardioprotection.
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Essential Polyunsaturated Fatty Acids in Blood from Patients with and without Catheter-Proven Coronary Artery Disease
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Autor/in / Beteiligte Person: | Wang, Chaoxuan ; Enssle, Jörg ; Pietzner, Anne ; Schmöcker, Christoph ; Weiland, Linda ; Ritter, Oliver ; Jaensch, Monique ; Elbelt, Ulf ; Pagonas, Nikolaos ; Weylandt, Karsten H. |
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Zeitschrift: | International Journal of Molecular Sciences, Jg. 23 (2022-01-11), Heft 766, p 766, S. 766-766 |
Veröffentlichung: | MDPI AG, 2022 |
Medientyp: | unknown |
ISSN: | 1422-0067 (print) |
DOI: | 10.3390/ijms23020766 |
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