Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response
In: Journal of Dermatological Science, Jg. 104 (2021-11-01), S. 122-131
Online
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Zugriff:
Background Both human and mouse allergic contact dermatitis (ACD) frequently demonstrates a combined type 1 and type 2 immune response. However, the relative importance of type 2 immunity in this setting has been incompletely understood yet. Objective To explore an effector function of type 2 immunity in ACD with mixed type 1/type 2 immune response. Methods Gene expression characteristics of contact hypersensitivity (CHS) model was examined by quantitative polymerase chain reaction. Cytokine profile of T cells was analyzed by flow cytometry. The involvement of type 2 immunity was assessed by antibody-mediated cytokine neutralization and cell depletion. The role of specific subset of cutaneous dendritic cells was evaluated using diphtheria toxin-induced cell-depleting mouse strains. Results Oxazolone-induced CHS revealed a combination of type 1/type 2 gene expression. The severity of oxazolone-induced CHS was ameliorated by neutralization of IL-4 but not of IFN-γ, indicating that type 2 immunity plays a dominant effector function in this mixed type 1/type 2 model. Mechanistically, type 2 effector immunity was mounted by CD301b+Langeirn− dermal dendritic cells in part through thymic stromal lymphopoietin-interleukin 7 receptor alpha signaling-dependent manner. Conclusion Our findings suggest the clinical rationale for targeting type 2 immunity as a relevant therapeutic strategy for the mixed immune phenotype of ACD.
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Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response
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Autor/in / Beteiligte Person: | Lee, Jaewon ; Oh, Jongwook ; Park, Jeyun ; Chang Ook Park ; Soo Min Kim ; Kim, Tae-Gyun ; Won Seok Roh ; Min Geol Lee ; Sung Hee Kim |
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Zeitschrift: | Journal of Dermatological Science, Jg. 104 (2021-11-01), S. 122-131 |
Veröffentlichung: | Elsevier BV, 2021 |
Medientyp: | unknown |
ISSN: | 0923-1811 (print) |
DOI: | 10.1016/j.jdermsci.2021.10.001 |
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