Achillea millefolium L. Essential Oil Inhibits LPS-Induced Oxidative Stress and Nitric Oxide Production in RAW 264.7 Macrophages
In: International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 14; Issue 7; Pages: 12978-12993 International Journal of Molecular Sciences, Jg. 14 (2013), Heft 7, S. 12978-12993
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Zugriff:
Achillea millefolium L. is a member of the Asteraceae family and has been used in folk medicine in many countries. In this study, 19 compounds in A. millefolium essential oil (AM-EO) have been identified; the major components are artemisia ketone (14.92%), camphor (11.64%), linalyl acetate (11.51%) and 1,8-cineole (10.15%). AM-EO can suppress the inflammatory responses of lipopolysaccharides (LPS)-stimulated RAW 264.7 macrophages, including decreased levels of cellular nitric oxide (NO) and superoxide anion production, lipid peroxidation and glutathione (GSH) concentration. This antioxidant activity is not a result of increased superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities, but rather occurs as a result of the down-regulation of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and heme oxygenase-1 (HO-1) expression, thus reducing the inflammatory response. Therefore, AM-EO can be utilized in many applications, including the treatment of inflammatory diseases in the future.
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Achillea millefolium L. Essential Oil Inhibits LPS-Induced Oxidative Stress and Nitric Oxide Production in RAW 264.7 Macrophages
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Autor/in / Beteiligte Person: | Hsu, Jaw-Cherng ; Lin, Chih-Chien ; Chou, Su-Tze ; Peng, Hsin-Yi ; Shih, Ying |
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Zeitschrift: | International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 14; Issue 7; Pages: 12978-12993 International Journal of Molecular Sciences, Jg. 14 (2013), Heft 7, S. 12978-12993 |
Veröffentlichung: | Molecular Diversity Preservation International (MDPI), 2013 |
Medientyp: | unknown |
ISSN: | 1422-0067 (print) |
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