SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish
In: Biochemical and Biophysical Research Communications, Jg. 511 (2019-04-01), S. 896-902
Online
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Zugriff:
Zinc (Zn) is an essential trace element that modulate innate and acquired immune responses, and its deficiency triggers lymphopenia. However, the precise mechanisms underlying zinc-mediated lymphocyte maintenance have not been well clarified. Here, we have successfully generated a zip6-null mutant zebrafish line using TALENs. The Zip6-null mutant zebrafish developed normally during gastrulation. Loss of zip6 in zebrafish resulted in significant T lymphocyte reduction and a decrease in intracellular Zn levels. And the zip6 deficiency increases caspase-related cell apoptosis in both zebrafish cells and human T cells. Our results suggest that ZIP6 plays a critical part in T cell development, and enhance our understanding of Zn homeostasis and immune system maintenance.
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SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish
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Autor/in / Beteiligte Person: | Shang, Zhen ; Yang, Yi ; Zhou, Jianfeng ; Jiang, Lijun ; Li, Tongjuan ; Wang, Gaoxiang ; Li, Dan ; Zhao, Lei ; Wang, Jue ; Tan, Jiaqi |
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Zeitschrift: | Biochemical and Biophysical Research Communications, Jg. 511 (2019-04-01), S. 896-902 |
Veröffentlichung: | Elsevier BV, 2019 |
Medientyp: | unknown |
ISSN: | 0006-291X (print) |
DOI: | 10.1016/j.bbrc.2019.02.148 |
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