Chemical composition and antinociceptive and anti-inflammatory activity of the essential oil of Hyptis crenata Pohl ex Benth. from the Brazilian Amazon
In: Journal of Ethnopharmacology, Jg. 300 (2023), S. 115720-115720
Online
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Zugriff:
The leaf tea of Hyptis crenata has its practical use in the Brazilian Amazon for treating gastrointestinal and liver disorders, sweating induction, and as an anti-inflammatory.Evaluation of the chemical composition, acute oral toxicity, and antinociceptive and anti-inflammatory activities of the H. crenata essential oil.The essential oil was hydrodistilled and analyzed by GC and GC-MS. The antinociceptive action in mice was evaluated for the peripheral and central analgesic activity (abdominal contortion and hot plate tests), and the xylene-induced ear swelling was carried out for the nociception test.Oxygenated monoterpenes (53.0%) and monoterpene hydrocarbons (38.9%) predominated in the H. crenata oil, being 1,8-cineo1e (35.9%), α-pinene (20.8%), camphor (10.0%), and β-pinene (7.3%) their primary constituents. The oral oil administration in the mice did not display changes in behavior patterns or animal mortality at 300 and 2000 mg/kg doses. The control group's biochemical parameters (ALP, AST, ALT) displayed a statistical difference from the treated group, unlike the renal parameters, which showed no variation between the groups. Oil reduced the abdominal contortions at doses of 100 (79.5%) and 300 mg/kg (44.4%), while with endodontacin, the dose was 5 mg/kg (75.2%). In addition, the oil could not decrease the paw licking/biting time at doses of 30, 100, and 300 mg/kg. However, it showed a significant antinociceptive effect on the second phase in the formalin test inhibiting licking time, with a reduction of 50.8% (30 mg/kg), 63.4% (100 mg/kg), 58.0% (300 mg/kg), and morphine (4 mg/kg, 78.3%). The oil administration produced significant inhibition of ear edema at all tested doses, with a better effect produced at 30 mg/kg (64.0% inhibition).The oil of Hyptis crenata, rich in 1,8-cineole, camphor, α-pinene, and β-pinene, totaling 74%, displayed low acute toxicity and significant anti-inflammatory activity, with peripheral and no central antinociceptive action. Thus, these results show an actual perspective on using H. crenata oil in developing a phytotherapeutic product.
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Chemical composition and antinociceptive and anti-inflammatory activity of the essential oil of Hyptis crenata Pohl ex Benth. from the Brazilian Amazon
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Autor/in / Beteiligte Person: | Maria Nancy N. de Lima ; Guimarães, Bruna A. ; Ana Lídia S. de Castro ; Ribeiro, Kevellen B. ; Miller, Daniele C. ; Pedro Iuri C. da Silva ; Jofre Jacob S. Freitas ; Anderson B. de Lima ; Setzer, William N. ; Joyce Kelly R. da Silva ; José Guilherme S. Maia ; Pablo Luis B. Figueiredo |
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Zeitschrift: | Journal of Ethnopharmacology, Jg. 300 (2023), S. 115720-115720 |
Veröffentlichung: | Elsevier BV, 2023 |
Medientyp: | unknown |
ISSN: | 0378-8741 (print) |
DOI: | 10.1016/j.jep.2022.115720 |
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