Effect of fixed dose combinations of metoprolol and amlodipine in essential hypertension: MARS – A randomized controlled trial
In: Blood Pressure, Jg. 20 (2011-10-13), S. 5-12
Online
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Zugriff:
To compare two strengths of a fixed drug combination (FDC) containing metoprolol XL and amlodipine (metoprolol/amlodipine 50/5; and metoprolol/amlodipine 25/2.5) with its components in hypertension.We conducted this multicentre, randomized, open-label, trial in Indian patients with hypertension (140-180 mmHg/90-114 mmHg) in 11 centres from nine cities. Eligible patients (n = 402) were randomized into one of five treatment groups (metoprolol XL 50 mg + amlodipine 5 mg, metoprolol XL 25 mg + amlodipine 2.5 mg, metoprolol XL 50 mg, metoprolol XL 25 mg or amlodipine 5 mg) and treated for 8 weeks with five follow-up visits to record blood pressure (BP) and clinical status.At baseline, treatment groups were well balanced; mean +/- SD BP was 154.87 +/- 11.91/96.63 +/- 6.97 mmHg. The greatest reduction in BP from baseline to 8 weeks was seen in the high-dose FDC group (23.61/14.91 mmHg; p0.001). The remaining 4 groups too demonstrated a significant reduction (p0.001): low-dose FDC - 22.29/ - 14.66; metoprolol 50, - 23.17/ - 13.37; metoprolol 25,- 18.41/ 12.50 and amlodipine 5, - 23.01/- 13.08. BP reductions by FDCs, however, were not statistically superior to monotherapies. Responder rates (sitting diastolic BP90 mmHg or reductionor =10 mmHg) were 93% in the high-dose FDC group and 97% in the low-dose FDC group, and control rates (sitting BP140/90 mmHg) were 66% and 58%, respectively. These rates were higher than that seen in individual components. There were no reports of serious adverse events related to study medications. One each from the low-dose FDC and metoprolol 25 mg group discontinued because of adverse events.FDCs of metoprolol and amlodipine are effective and safe in mild to moderate hypertension.
Titel: |
Effect of fixed dose combinations of metoprolol and amlodipine in essential hypertension: MARS – A randomized controlled trial
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Autor/in / Beteiligte Person: | Bosco, Balraj ; Sigamani, Alben ; Murthy, Sreenivas ; Xavier, Denis ; Devi, Padmini ; Nambiar, Ashokan ; Gupta, Rajeev ; Joshi, Sindhu ; Singh, Girija ; Mehta, Ketan ; Thomas, Tinku ; Pais, Prem ; Sharma, Kamal ; Hiremath, Jagadish ; Pandey, Sudhanshu ; Ds, Chadha |
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Zeitschrift: | Blood Pressure, Jg. 20 (2011-10-13), S. 5-12 |
Veröffentlichung: | Informa UK Limited, 2011 |
Medientyp: | unknown |
ISSN: | 1651-1999 (print) ; 0803-7051 (print) |
DOI: | 10.3109/08037051.2011.617040 |
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