CXCL12 Signaling Is Essential for Maturation of the Ventricular Coronary Endothelial Plexus and Establishment of Functional Coronary Circulation
In: Developmental cell, Jg. 33 (2014-07-24), Heft 4
Online
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Zugriff:
SummaryMaturation of a vascular plexus is a critical and yet incompletely understood process in organ development, and known maturation factors act universally in all vascular beds. In this study, we show that CXCL12 is an organ-specific maturation factor of particular relevance in coronary arterial vasculature. In vitro, CXCL12 does not influence nascent vessel formation, but promotes higher-order complexity of preinitiated vessels. In the heart, CXCL12 is expressed principally by the epicardium, and its receptor CXCR4 is expressed by coronary endothelial cells. CXCL12 is not a chemotactic signal for endothelial cell migration, but rather acts in a paracrine manner to influence the maturation of the coronary vascular plexus. Mutants in CXCL12 signaling show an excess of immature capillary chains and a selective failure in arterial maturation, and become leaky with the onset of coronary perfusion. Failed maturation of the coronary system explains the late-gestation lethality of these mutants.
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CXCL12 Signaling Is Essential for Maturation of the Ventricular Coronary Endothelial Plexus and Establishment of Functional Coronary Circulation
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Autor/in / Beteiligte Person: | Lien, Ching-Ling ; S. Ram Kumar ; Shen, Hua ; Yi, Christopher ; Sucov, Henry M. ; Cavallero, Susana |
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Zeitschrift: | Developmental cell, Jg. 33 (2014-07-24), Heft 4 |
Veröffentlichung: | 2014 |
Medientyp: | unknown |
ISSN: | 1878-1551 (print) |
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