Effect of Lacidipine on Blood Pressure and Endothelial Function in Mild-to-Moderate Essential Hypertension Patients With Diabetes in Korea
In: Korean Circulation Journal, Jg. 40 (2010), S. 632-632
Online
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Zugriff:
Background and Objectives: The aim of this study was to evaluate the efficacy of lacidipine in reducing blood pressure (BP) and to determine its effect on endothelial function in mild-to-moderate hypertensive patients with type 2 diabetes mellitus (DM). Subjects and Methods: This was a prospective, multicenter, open-label, single-arm study, enrolling 290 patients with mild-to-moderate hypertension and type 2 DM. Patients were initially treated with 2 mg lacidipine orally once daily for 4 weeks, which was then increased as necessary every 4 weeks to a maximal dose of 6 mg daily. The primary endpoint was the mean change in systolic blood pressure (SBP) from baseline after 12 weeks of treatment. Secondary endpoints included mean changes in diastolic blood pressure (DBP), flow-mediated vasodilatation (FMD), and serum concentrations of biochemical markers such as high-sensitivity C-reactive protein (hs-CRP), monocyte chemo-attractant protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9), and plasminogen activator inhibitor-1 (PAI-1). Results: Lacidipine treatment significantly reduced SBP by -13.4±13.0 mmHg (p
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Effect of Lacidipine on Blood Pressure and Endothelial Function in Mild-to-Moderate Essential Hypertension Patients With Diabetes in Korea
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Autor/in / Beteiligte Person: | Kim, Hyo-Soo ; Si Hoon Park ; Min Su Hyon ; Kim, Yong-Jin ; Choi, So-Yeon ; Myung Ho Jeong ; Young Dae Kim ; Doo Il Kim ; Kyu Hyung Ryu ; Tae Hoon Ahn ; Sung Yun Lee ; Il Young Oh ; Si Wan Choi ; Sang Hong Baek ; Hae Young Lee ; Kwon Sam Kim ; Wook Sung Chung ; Cheol Ho Kim ; Byung Hee Oh ; Kim, Dae-Hee ; Seung Hwan Lee ; Seok Kyu Oh ; Dong Gu Shin ; Jun Young Jeong ; Wan Joo Shim |
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Zeitschrift: | Korean Circulation Journal, Jg. 40 (2010), S. 632-632 |
Veröffentlichung: | The Korean Society of Cardiology, 2010 |
Medientyp: | unknown |
ISSN: | 1738-5555 (print) ; 1738-5520 (print) |
DOI: | 10.4070/kcj.2010.40.12.632 |
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